Journal/Ingredients & evidence
The complete evidence guide

The research behind our Retinol Alternative Moisturiser

Every active ingredient in the moisturiser, the published research behind it, what that research measured, and what it doesn't prove. Written so you can judge it yourself.

Elurelia EditorialUpdated 25 September 202620 min read12 references
Photo 01 · Hero · The moisturiser bottle lying beside a printed page of a study, flat lay from above, text out of focus, soft daylight. No people. · 2400×1030 · 21:9

Every ingredient discussed here is in the moisturiser. Not every study used the same concentration as ours, and we say so each time.

Key takeaways
1Bidens Pilosa is the retinol alternative. In a lab study it raised collagen and elastin in human skin cells and acted on the same receptors retinol uses. Nobody has tested it against retinol on faces yet. 2The hydrators have the best human evidence. Hyaluronic acid, aloe, glycerin and sodium PCA have measured results on real skin, which is why comfort shows first. 3Two supporting actives rest on their makers' data. Dipalmitoyl hydroxyproline and Alteromonas ferment extract are promising, and their evidence comes from the companies that sell them. 4The finished formula was rated by users. In consumer-perception testing on our formula, 95% said their skin felt instantly comforted and 95% said it felt more hydrated. 5Give it twelve weeks. Hydration shows in days, texture in weeks, lines last.

A moisturiser is the product you use most. It goes on every morning and every evening, often for years. So it's worth knowing what each ingredient in it is there to do, and how good the evidence for that really is.

This guide goes through the Retinol Alternative Moisturiser one ingredient at a time. For each, we say what was tested, on whom, what was found, and what the finding doesn't prove. Several ingredients are shared with our serum. Where we've already written about them in full, we summarise here and link to the longer version.

If you only want the product details, the moisturiser page has them.

01What is a retinol alternative moisturiser?

A retinol alternative moisturiser is a daily face cream that contains an ingredient chosen to work on the same skin pathways as retinol, without being a form of vitamin A. The idea is simple: many people want the smoother-looking, more even skin that retinol is known for, and a lot of them can't live with what retinol does in the first weeks.

Retinol itself is a vitamin A derivative. Skin converts it, in two steps, into retinoic acid, which binds to receptors inside skin cells and changes how they behave. That's why it works, and it's also why it irritates: the change is strong, and skin often responds with dryness, flaking, redness and stinging. Most retinol routines start slowly, stay at night, and ask you to buffer the product with a separate moisturiser.

A retinol alternative sidesteps vitamin A altogether. The best-known options are bakuchiol, from babchi seeds, and Bidens Pilosa, from a wild herb in the daisy family. Neither is vitamin A, neither is restricted under the EU's 2025 vitamin A rules, and neither needs an adjustment period. What differs is the evidence behind each, which is what the rest of this guide is about.

Putting the alternative into a moisturiser, rather than only a serum, has a practical advantage. A moisturiser is the one product almost everyone uses every day, morning and night. Consistency matters more than strength for most skin, and it's much easier to be consistent with a step you'd take anyway.

In one lineOur Retinol Alternative Moisturiser is a light daily cream with 2% Bidens Pilosa extract, sodium PCA and two forms of hyaluronic acid. It is 99% natural origin, certified COSMOS Natural, and you can use it morning and evening from the first day.

02Retinol cream vs retinol alternative moisturiser

If you're deciding between the two, the differences come down to evidence, comfort and how the product fits your day.

A retinol cream Our retinol alternative moisturiser
Active Retinol, a vitamin A derivative 2% Bidens Pilosa extract, no vitamin A
Evidence Decades of human clinical trials Lab studies, plus consumer testing on our formula
First weeks Dryness, flaking and stinging are common No adjustment period expected
When to use Usually evenings only, introduced slowly Morning, evening, or both, from day one
EU rules Face products limited to 0.3% retinol equivalent since November 2025 Not restricted
In pregnancy Generally avoided No vitamin A; ask your doctor
Daily SPF Essential Recommended, as with any skincare

Retinol wins on evidence, and we won't pretend otherwise. If your skin tolerates it and you want the most proven option for visible lines, it's a strong choice, and our full retinol guide explains how to use it well. Where the alternative wins is in daily life: it goes on in the morning, it doesn't need a slow start, and it doesn't ask your skin to put up with weeks of discomfort before anything improves.

That trade-off is the whole reason this moisturiser exists. It's for the people who tried retinol, stopped, and still want a product in their routine that's built around the same idea.

03How we rate the evidence

Skincare research comes in very different strengths, and most product pages treat them all the same. We use four labels, strongest first.

Label What it means
Human trial People used the ingredient on their skin and it was measured, ideally against a placebo.
Review Researchers collected many earlier studies. Useful for the overall picture, and only as good as the studies in it.
Lab Cells or skin samples in a dish. Good for showing how something might work. It can't tell you what happens on a face.
Maker's data Tests run or paid for by the company that sells the ingredient, often with details unpublished.

None of these studies tested our moisturiser. They tested an ingredient, usually at a known strength in a different product. The only results for our exact formula are the consumer-perception figures in section 11.

04Bidens Pilosa, in depth

Bidens Pilosa extract

Evidence: lab

Bidens Pilosa, also called Black Jack, is a wild herb from the daisy family. Its extract contains phytol, a plant compound that the body can convert into phytanic acid. Phytanic acid is known to act on RXR receptors, one of the two receptor families that retinoids work through. That link is why it's sold as a retinol alternative.

StudyDieamant et al., 2015. Evidence-Based Complementary and Alternative Medicine.
What was testedA standardised extract of Bidens Pilosa made with supercritical CO₂, applied to cultured human skin cells (fibroblasts) and to fragments of human skin in a lab. It was compared with 10 μM retinol and 10 μM retinoic acid.
What they foundCollagen rose by 32.5% at the lowest dose tested (retinol: 45.6%, retinoic acid: 62.9%). Elastin rose by 25.2% at the highest dose (retinol: 16.7%). The extract, and phytol on its own, switched on retinoid receptor genes, and growth-factor levels in the cells rose.
What it doesn't proveIt doesn't show any change in wrinkles on a person. Cells in a dish respond more directly than skin on a face, where an ingredient has to get through the outer layer first. Most of the authors worked for Chemyunion, a Brazilian cosmetic-ingredient company.
Our concentration2% Bidens Pilosa extract. The study measured the extract in milligrams per millilitre of cell culture, which doesn't translate into a percentage in a cream, and we can't confirm our extract is the same grade.
Our readingA credible reason to include it, and an early one. We'd rather tell you it's lab evidence than let the collagen numbers do more work than they can.
Original sources
  1. Dieamant G. et al. Antiageing mechanisms of a standardized supercritical CO₂ preparation of Black Jack (Bidens pilosa L.) in human fibroblasts and skin fragments. Evid Based Complement Alternat Med, 2015:280529. Read the source
Where Bidens Pilosa is in our range Our moisturiser carries 2% Bidens Pilosa in a light cream you can use twice a day. 60-Day Promise on your first order, conditions apply.

05Sodium PCA

Sodium PCA

Evidence: review

The outer layer of your skin holds water with a mix of small molecules called natural moisturising factor. PCA (pyrrolidone carboxylic acid) is the largest single part of it. Sodium PCA is its salt, and it draws water in the same way. Dry skin tends to have less of it.

StudyClar & Fourtanier, 1981. International Journal of Cosmetic Science (review).
What was testedA review of the research on PCA and the skin, including the authors' own tests of cosmetic creams containing PCA or its salts, run over several years.
What they foundPCA worked as a hydrating agent, and the creams containing at least 2% PCA or PCA salt improved dry skin in both short and long-term use.
What it doesn't proveIt is an older review and much of it describes the authors' own work, without the placebo-controlled design a modern trial would use. A later study (Feng et al., 2014, 64 women) found that dry skin had lower PCA levels. That shows a link and doesn't show that adding PCA fixes dryness.
Our concentrationNot published. Sodium PCA is eighth on our list, after water, which suggests a small percentage. We don't know if it reaches 2%.
Original sources
  1. Clar E.J., Fourtanier A. Pyrrolidone carboxylic acid and the skin. Int J Cosmet Sci 3(3):101–113, 1981.
  2. Baumann L. Pyrrolidone carboxylic acid may be a key cutaneous biomarker. Dermatology News, 2020 (summary of Clar & Fourtanier and Feng et al.). Read the source

06Hyaluronic acid, aloe and glycerin

These three are shared with our serum, and we've written about each in full in the serum research guide. Here are the essentials.

Hyaluronic acid, two forms

Evidence: human trial
StudyPavicic et al., 2011. Journal of Drugs in Dermatology.
What was tested76 women aged 30–60 applied a 0.1% hyaluronic acid cream around one eye twice a day for 60 days, with a plain cream around the other. Five molecular weights were tested.
What they foundEvery size improved hydration and elasticity against the plain cream. Only the two smallest (50 and 130 kDa) also reduced measured wrinkle depth.
What it doesn't proveIt tested the eye area, in a different cream. It doesn't tell you how our formula performs.
In our formulaSodium hyaluronate for surface hydration, plus hydrolysed hyaluronic acid, the smaller form. The percentages aren't published.

Organic aloe leaf juice

Evidence: small human trial
StudyDal'Belo et al., 2006. Skin Research and Technology.
What was tested20 women applied creams with 0.10%, 0.25% or 0.50% freeze-dried aloe to the inner forearm daily for two weeks, against the same cream without aloe.
What they foundEvery aloe concentration raised the water content of the skin's outer layer. Water loss through the skin didn't change.
What it doesn't proveIt was small, on the forearm, and used freeze-dried aloe. It says nothing about lines.
In our formulaFirst on the list, so it is the largest single ingredient.

Glycerin

Evidence: review
StudyFluhr, Darlenski & Surber, 2008. British Journal of Dermatology (review).
What they foundAcross decades of research, glycerol applied to skin improves hydration of the outer layer, supports barrier function and helps protect against irritants.
What it doesn't proveIt summarises other products' data. It isn't a test of ours.
In our formulaThird on the list, made using organic ingredients.
Original sources
  1. Pavicic T. et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. J Drugs Dermatol 10(9):990–1000, 2011.
  2. Dal'Belo S.E., Gaspar L.R., Maia Campos P.M. Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations. Skin Res Technol 12(4):241–246, 2006.
  3. Fluhr J.W., Darlenski R., Surber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol 159(1):23–34, 2008.

07Jojoba and the butters

Organic jojoba seed oil

Evidence: review

Jojoba is second on the list, which makes it the main oil in the cream. It is technically a liquid wax, chemically close to the oils your skin produces, and it's the reason the moisturiser feels silky rather than greasy.

StudyPazyar et al., 2013. Giornale Italiano di Dermatologia e Venereologia (review).
What they foundAcross the studies reviewed, jojoba showed anti-inflammatory activity and is widely used in moisturisers and products for ageing skin.
What it doesn't proveIt's a review of mixed, mostly small studies. Count it as supporting evidence.

The murumuru and mango seed butters make it a cream and give it slip. We make no claim for them beyond comfort. There is more on these in the serum guide.

Original sources
  1. Pazyar N. et al. Jojoba in dermatology: a succinct review. G Ital Dermatol Venereol 148(6):687–691, 2013.

08Dipalmitoyl hydroxyproline

Dipalmitoyl hydroxyproline

Evidence: maker's data

Hydroxyproline is an amino acid found in the skin's supporting structure. On its own it dissolves in water and doesn't sink into skin well. Joining it to two chains of palmitic acid makes it oil-soluble, and that is what dipalmitoyl hydroxyproline is. It sits ninth on our list, which is fairly high for an active.

EvidenceData from the ingredient's maker, plus a 2026 dermatology overview of cosmetic peptides.
What is reportedThe maker reports that it moisturises and firms, and gives a 32% reduction in wrinkles against placebo in volunteers. The 2026 overview describes the supporting trials as industry-sponsored.
What it doesn't proveWe found no independent, peer-reviewed human trial. The maker hasn't published panel size, study length or method alongside the 32% figure, so we can't check it.
Our concentrationNot published. Makers recommend 0.1–2% in finished products.
Our readingIt has a sensible rationale and a good safety record in cosmetics. The results claimed for it haven't been independently tested, so we list it as supporting, and keep it off the front of the pack.
Original sources
  1. Seppic. SEPILIFT DPHP (dipalmitoyl hydroxyproline), ingredient information. Read the source
  2. The peptide prescription: decoding the evidence, from topicals to longevity. Healio Dermatology, July 2026. Read the source

09Alteromonas ferment extract

Alteromonas ferment extract

Evidence: lab + maker's volunteer test

Some marine bacteria produce long sugar chains, called exopolysaccharides, to protect themselves. Fermented and purified, these form a thin, invisible film on the skin. Several different commercial ingredients share this INCI name.

StudyBorel, Lamarque & Loing, 2017. Journal of Cosmetic Science.
What was testedA purified exopolysaccharide on skin cells exposed to UVB in a lab, and on volunteers' skin before and after exposure to fine dust particles.
What they foundIn cells, it reduced UV-linked damage to cell fats. On volunteers, 0.02% applied beforehand cut the number of particles sticking to skin by 45% against placebo, and in a rinse it removed 27% more particles.
What it doesn't proveThe authors work for the company that makes the ingredient. Particles sticking less to skin isn't the same as any visible change. We don't know if our grade is the one tested, or at what strength.
Original sources
  1. Borel M., Lamarque E., Loing E. Unique natural exopolysaccharides for biomimetic protective effect against urban pollution. J Cosmet Sci 68(1):126–132, 2017. Read the source

10Vitamin C and E, honestly

You may see this moisturiser described elsewhere as containing vitamin C. It does, in a small way. The vitamin C is ascorbyl palmitate, an oil-soluble form, and it sits 27th of 39 ingredients, right after tocopherol (vitamin E). At that point on the list, both are there mainly to keep the plant oils from going off.

That is useful, and it isn't what a vitamin C serum does. We don't sell this as a vitamin C product and we don't claim brightening from it. The brightness figures in the consumer testing are for the formula as a whole.

11Testing on this exact formula

Everything above tests single ingredients. The only results for our finished moisturiser come from consumer-perception testing: people used it and rated their own skin.

Group What people reported
Comfort & hydration 95% instantly comforted skin · 95% noticeably more hydrated
Lifting & smoothing 85% an instant lifting effect · 85% a lifting sensation all day · 85% smoother-looking skin · 85% improved-looking texture · 80% a tightening effect on pores
Radiance & tone 80% more radiant · 80% visibly brighter · 75% more even tone · 75% dark spots less visible · 75% pigmentation minimised · 70% blemishes less visible
Lines & wrinkles 80% lines looked reduced · 80% lines looked improved · 75% wrinkles looked reduced
Overall 90% an overall improved appearance
What we don't have yetThe panel size, the study length and the testing lab haven't been published alongside these figures. We've asked for the full report. When it arrives, it goes here and on the product page, whatever it says.

Read the pattern rather than any single number. Comfort and hydration scored highest, which fits the strength of the evidence for the hydrators. Lines scored lowest and take longest, which fits the lab-only evidence for Bidens Pilosa.

12How to choose a retinol alternative moisturiser

The label "retinol alternative" isn't regulated, so products vary a lot. These six checks work on any brand, ours included. A good product should pass most of them.

✓The active is named, with a percentage. "With plant retinol" tells you nothing. Look for the ingredient and how much of it is in the product. Ours: 2% Bidens Pilosa extract.
✓The full ingredient list is published. Every ingredient, in order, on the product page. Ours has 39, and all of them are printed.
✓Fragrance allergens are named. If a product is scented, the declared allergens should be listed, not hidden in "parfum". Ours declares four: Geraniol, Citronellol, Linalool and Citral.
✓The evidence is described honestly. Lab studies, human trials and consumer testing are different things. A brand that tells you which is which is more trustworthy than one that claims more than its evidence shows.
✓The base does real work. The hydrating ingredients are what you'll feel first. Look for humectants with good evidence, such as glycerin, hyaluronic acid and sodium PCA.
✓It's independently certified. A recognised standard such as COSMOS Natural means the formula was checked by someone other than the brand.

Our moisturiser passes all six. The one thing it isn't is fragrance-free, and if you need that, it isn't the right product for you. You can check every claim above against the full formula on the product page.

13How to use it for the best results

Good ingredients only work if they're used consistently. This is the routine we'd suggest.

Step Morning Evening
1 Cleanse, or rinse with water Cleanse, removing SPF and makeup
2 Serum, if you use one Serum, if you use one
3 Retinol Alternative Moisturiser, a pea-sized amount Retinol Alternative Moisturiser
4 SPF 30 or higher Nothing else needed

Warm a small amount between your fingertips and smooth it over your face and neck. A pea-sized amount is enough for most faces, and a 50 ml bottle lasts about two months used twice a day. If you use our Retinol Alternative Serum, apply it first and let it settle for a minute.

If your skin is reactive, patch test first: apply a little to your inner forearm once a day for five days. And judge it fairly. Hydration shows within days, texture over a few weeks, and fine lines take around twelve weeks with any product, retinol included.

Not sure whether you need the serum, the moisturiser or both? Our serum-or-moisturiser guide answers that in a few minutes.

14Who it suits, and who should skip it

It suits you if retinol left your skin flaky, tight or stinging; you want one moisturiser for morning and night; your skin feels dry or tight and you want comfort first; or you want to see every ingredient and allergen before you buy.

Skip it, or check first, if you need a fragrance-free product; you react to ragweed, daisies or chamomile, since Bidens Pilosa is in the same family; you're pregnant or breastfeeding and haven't asked your doctor; or you want a rich night cream for very dry skin. If you want the plant alternative with the strongest human evidence, read bakuchiol vs Bidens Pilosa.

15What it adds up to

This is a well-built moisturiser with strong evidence where moisturisers usually have it: hydration and comfort. On top of that, it carries a retinol alternative with a credible mechanism and early, lab-only evidence, plus two supporting actives whose evidence comes from their makers.

If you want the best-evidenced route to fewer visible lines, that is still retinol, and our retinol guide explains when it's worth it. If retinol didn't suit you, this is a gentle daily step you can use morning and night. If you're deciding between this and our serum, our serum-or-moisturiser guide will help, and bakuchiol vs Bidens Pilosa compares the two plant alternatives.

16Your questions, answered

Is a retinol alternative moisturiser as good as retinol?

Not on evidence. Retinol has decades of clinical trials; Bidens Pilosa has lab studies and our consumer testing. What the alternative offers is comfort and flexibility: no adjustment period, and you can use it morning and night.

Can I use a retinol alternative moisturiser every day?

Yes. It's designed for twice-daily use from the first day, with no slow introduction.

Can I use it with retinol?

You can, though you don't need to. If you do, keep retinol in the evening and use the moisturiser in the morning, or after retinol at night.

Is Bidens Pilosa safe for sensitive skin?

It's generally well tolerated, and 95% of testers said our formula felt instantly comforting. It is a daisy-family plant, so patch test first if you react to ragweed, daisies or chamomile.

Does it contain vitamin A?

No. Neither Bidens Pilosa nor any other ingredient in the formula is a form of vitamin A.

How long does a bottle last?

About two months used morning and evening, at a pea-sized amount each time.

Does the 60-Day Promise apply?

Yes, on your first order, conditions apply. Use it daily for 60 days, and if your skin hasn't changed the way you hoped, email us between day 60 and day 90 for a refund of the product price.

Retinol Alternative Moisturiser 2% Bidens Pilosa in a light daily cream, with every ingredient printed in full. 60-Day Promise on your first order, conditions apply.

This article is for general information and isn't medical advice. Cosmetic product: all claims describe the appearance of skin.

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